Pre-transfusion compatibility tests in sickle cell disease


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Introduction: Blood transfusion is a key component of sickle cell disease
management. However, iterative transfusions of labile blood products for
sickle cell patients increase the risk of anti-erythrocyte alloimmunization.
It is usual to perform pre-transfusion compatibility tests in order to check
ABO compatibility and to detect the possible existence of irregular antibodies in patients against the donor’s antigens.
Methods: This is a prospective and descriptive study dealing with pre-transfusion compatibility tests over a 3-month period, from September 2018
to November 2018, at the Regional Blood Transfusion Centre (CRTS) of
Analamanga Region, the capital of Madagascar.

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