Effects of Blood Donation Frequencies and types of Blood Donors on Storage Lessions as assessed by the level of antioxidants and Lipid Peroxidation

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Lawal, S.A. Ugbomoiko, D Muhibi M.A Olatunbosun, L.O, Shittu A. Olalere, F.D. Ogunwale KAT, Ibrahim, S.E. Abdul Raheem, A.A. and Lawal, I.K. 

AJLHTS: Original Paper   DOI – ajlhtsonline.org/doi-org-10-59708-ajlhts-v2i2-2324/


Introduction: Influence of Blood storage lesions on Red Blood Cells transfusion recovery and therapeutic efficacies have been well documented. Several stabilizing additives to counteract or minimize these untoward changes have been formulated. Despite these stabilizers, detectable hemolysis occurs in the blood stored in the blood bank hence, need for search on other contributing factors. Assessment of the effects of Blood Donation Frequencies and Types of Blood Donors on Storage Lesions as Assessed by the Level of Antioxidants and Lipid Peroxidation. 

Materials and Methods Ethically approved cross sectional experimental research on a total numbers of 120 recruited male of family replacement donors (n=30) and Remunerated donors (n=90). Remunerated donors were grouped into three (3) based on the frequency of donation per year as mild (n=30), moderate (n=30) and high frequency (n=30) donors. Four hundred and fifty milliliters (450 ml) of blood drawn from each donor into double blood bag containing CPDA-1 anticoagulant. 100 ml of well mixed blood was transferred into the satellite bag, detached and stored in the blood bank at 2-6 C for 35 days. The blood samples analyzed for MDA, TAP, URIC, and GSH at 0, 7, 14, 21, 28 and 35 days of storage. Results: In the recruited donors, majority were above 40 years of age where family donors had secondary education, government employed; feed majorly on carbohydrate,

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