The Trajectory of Haptoglobin in Haemolysis, Inflammation and Transfusion Reaction


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Background: Haptoglobin is an acute-phase α2-glycoprotein
produced in the liver with the major biological function of binding
free haemoglobin with very high affinity to prevent the loss of
iron following hemolysis. Haptoglobin has an anti-inflammatory
property and is raised during inflammation whereas, low level is
associated with haemolysis. Transfusion is linked with haemolysis
thereby increasing the level of free haemoglobin due to antihaptoglobin and storage effect. Studies have revealed interplay of
haptoglobin in haemolysis, inflammation and transfusion reaction
although, the underlying mechanism is not well understood.
Besides, its utilization as a diagnostic biomarker and therapeutic
advantage have not been well explored hence, this study.
Method: In this review 20 primary studies from various electronic databases such as Google scholar, Semantic scholar and PubMed were obtained on
the basis that they were focused on haptoglobin, haptoglobin in haemolysis,
inflammation and transfusion. This was made possible by the use of Boolean function

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