Phagocytic Functions of Peripheral Blood Neutrophil In Subjects with Leukaemia

DOI URL: 10.59708/ajlhts.v3i3.abs.1

 

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Abstract
Background: An efficient immune system is crucial for the host to mount a sufficient immune response, particularly in times of disease and traumatic injury. In leukaemia, regardless of the type, the abnormal cells in the bone marrow suppress the formation of other cells, leading to several adverse effects. Our research suggests that the traditional innate immune functions of neutrophils might be impaired in subjects with leukaemia, which could have significant implications for the immune system’s response to disease and injury.

Pathogen Inactivation: Blood Transfusion Laboratory Preparedness To Pandemic

DOI URL: 10.59708/ajlhts.v3i3.abs.2

 

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Abstract
Introduction:
Insufficient focus on pandemic response in African transfusion services stems from a lack of specialized facilities for detecting
current and emerging Transfusion-Transmissible Infections (TTIs), which underscores the essential requirement for a Pathogen Inactivation System (PIS).

Effect of Storage Temperature on D-Dimer Stability In Different Abo Blood Groups

DOI URL: 10.59708/ajlhts.v3i3.abs.3

 

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Abstract
Introduction:
D-dimer is an invaluable analyte in evaluating thrombin and plasmin activity and is specific for fibrin derivatives. This study assessed
the effects of storage temperatures on D-dimer stability in different ABO blood types stored over a defined period. The study was performed with 40 samples collected randomly from apparently healthy male and female  undergraduate students of Rivers State University, Port-Harcourt, all aged between 17 and 45 years.

Iron Deficiency Anaemia And Beta-Thalassaemia Differentiation In Pregnant Women Attending Tertiary Hospital In Port-Harcourt Based On Mentzer Index

DOI URL: 10.59708/ajlhts.v3i3.abs.4

 

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ABSTRACT
Introduction:
The Mentzer index is a cost-effective and accurate method for differentiating between iron deficiency anaemia (IDA) and beta-thalassaemia.
Anaemia in pregnancy is a global health concern, especially in developing countries like Nigeria, where it is primarily linked to iron deficiency and may also include other underlying haemoglobin disorders, with beta-thalassaemia  (βT) being the most common. This cross-sectional study aimed to differentiate between iron deficiency anaemia and beta-thalassaemia in pregnant women
attending tertiary hospitals in Port Harcourt, Nigeria, based on the Mentzer Index.

Haemostatic Biomarker and Platelet Indices Dynamics Among End Stage Renal Disease in Yola & Gombe

DOI URL: 10.59708/ajlhts.v3i3.abs.5

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Abstract
Introduction:
Renal insufficiency, a global pandemic, is rapidly gaining attention, affecting over 800 million people (>10%) worldwide. Tragically, millions succumb each year due to haemostatic dysfunction and negative thromboembolic dynamics. Haemostatic biomarkers measure the integrity
and dynamics of haemostasis. Therefore, this study aims to evaluate these biomarkers and platelet indices to elucidate the dynamics of the
haemostatic system in ESRD.

Evaluation of Some Haematologic and Hemostatic Changes in Breast Cancer Patients

DOI URL: 10.59708/ajlhts.v3i3.abs.6

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Abstract
Introduction:
Haematological parameters have been shown to predict  severity, mortality and treatment follow-up in breast cancer patients as well
as the interaction between tumour and haemostatic functions. This study shows the changes in haematological and haemostatic parameters and the corresponding effect of chemotherapy on haematological parameters.

Evaluation Of Coagulation Factors F VII, F XII, Von Willebrand Factor, And Adamts 13 In Tuberculosis Disease Subjects Undergoing Treatment In Yenagoa Bayelsa State.

DOI URL: 10.59708/ajlhts.v3i3.abs.7

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Abstract:
Introduction:
Tuberculosis, a significant health concern and leading infectious disease in man, is caused by Mycobacterium tuberculosis. Research shows that Tuberculosis affects the coagulation factors and causes elongated Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) in infected subjects. This study was carried out to evaluate coagulation factors VII, XII, ADAMTS 13, and vWF in TB disease and treatment.

The Impact of Ibuprofen, Diclofenac, and Piroxicam on the Full Blood Count of Wistar Albino Rats

DOI URL: 10.59708/ajlhts.v3i3.abs.8

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Abstract
Introduction:
The sensation of pain is intricate, involving diverse pathways responsible for the generation (transduction) and transmission (propagation)
of nociceptive signals. This process encompasses the perception and control of stimuli that induce pain.

Exploring The Impact Of Non-Steroidal Anti-Inflammatory Drugs On Blood Cell Morphology: A Comprehensive Study Across a Variety Of Blood Cell Types In Wistar Albino Rats

DOI URL: 10.59708/ajlhts.v3i3.abs.9

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Abstract
Introduction:
Although NSAIDs are widely used for inflammation and pain relief, limited research exists on how these drugs may affect the morphology of bloodcells. The precise impact of NSAIDs on blood cell shape remains poorly understood despite their widespread usage.

Evaluation Of Blood Supply And Usage Pre- And During Covid-19 Pandemic: A Lesson From Non-Voluntary Donation

DOI URL: 10.59708/ajlhts.v3i3.abs.10

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Abstract
Introduction:
The ultimate goal of blood transfusion practice is to ensure a steady stream of safe blood. The current COVID-19 pandemic has affected almost every part of life and the economy. Consequently, this study aims to assess the effect of the pandemic on blood supply and blood transfusion in the University of Calabar Teaching Hospital.