Author: ajlhtsonline

Abstract

Background: An efficient immune system is crucial for the host to mount a sufficient immune response, particularly in times of disease and traumatic injury. In leukaemia, regardless of the type, the abnormal cells in the bone marrow suppress the formation of other cells, leading to several adverse effects. Our research suggests that the traditional innate immune functions of neutrophils might be impaired in subjects with leukaemia, which could have significant implications for the immune system’s response to disease and injury.

Abstract

Introduction:

Insufficient focus on pandemic response in African transfusion services stems from a lack of specialized facilities for detecting

current and emerging Transfusion-Transmissible Infections (TTIs), which underscores the essential requirement for a Pathogen Inactivation System (PIS).

Abstract

Introduction:

D-dimer is an invaluable analyte in evaluating thrombin and plasmin activity and is specific for fibrin derivatives. This study assessed

the effects of storage temperatures on D-dimer stability in different ABO blood types stored over a defined period. The study was performed with 40 samples collected randomly from apparently healthy male and female  undergraduate students of Rivers State University, Port-Harcourt, all aged between 17 and 45 years.

ABSTRACT

Introduction:

The Mentzer index is a cost-effective and accurate method for differentiating between iron deficiency anaemia (IDA) and beta-thalassaemia.

Anaemia in pregnancy is a global health concern, especially in developing countries like Nigeria, where it is primarily linked to iron deficiency and may also include other underlying haemoglobin disorders, with beta-thalassaemia  (βT) being the most common. This cross-sectional study aimed to differentiate between iron deficiency anaemia and beta-thalassaemia in pregnant women

attending tertiary hospitals in Port Harcourt, Nigeria, based on the Mentzer Index.

Abstract

Introduction:

Renal insufficiency, a global pandemic, is rapidly gaining attention, affecting over 800 million people (>10%) worldwide. Tragically, millions succumb each year due to haemostatic dysfunction and negative thromboembolic dynamics. Haemostatic biomarkers measure the integrity

and dynamics of haemostasis. Therefore, this study aims to evaluate these biomarkers and platelet indices to elucidate the dynamics of the

haemostatic system in ESRD.

Abstract

Introduction:

Haematological parameters have been shown to predict  severity, mortality and treatment follow-up in breast cancer patients as well

as the interaction between tumour and haemostatic functions. This study shows the changes in haematological and haemostatic parameters and the corresponding effect of chemotherapy on haematological parameters.

Abstract:

Introduction:

Tuberculosis, a significant health concern and leading infectious disease in man, is caused by Mycobacterium tuberculosis. Research shows that Tuberculosis affects the coagulation factors and causes elongated Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) in infected subjects. This study was carried out to evaluate coagulation factors VII, XII, ADAMTS 13, and vWF in TB disease and treatment.

Abstract

Introduction:

Although NSAIDs are widely used for inflammation and pain relief, limited research exists on how these drugs may affect the morphology of bloodcells. The precise impact of NSAIDs on blood cell shape remains poorly understood despite their widespread usage.

Abstract

Introduction:

The ultimate goal of blood transfusion practice is to ensure a steady stream of safe blood. The current COVID-19 pandemic has affected almost every part of life and the economy. Consequently, this study aims to assess the effect of the pandemic on blood supply and blood transfusion in the University of Calabar Teaching Hospital.