Author: ajlhtsonline

Introduction: The rationale for age-related changes in the hemostatic system remains unraveled, and there is a need for age-specific reference ranges. This study evaluated some of the coagulation factors among the children and compared the values to the adult’s values, all subjects residing in Nnewi, Southeast Nigeria.

Introduction: Understanding the expression of the erythropoietin gene is crucial as it plays a central role in the body’s response to anaemia in sickle cell patients. Studies on erythropoietin gene

expression have been instrumental in elucidating the mechanism by which cells and tissues detect hypoxia. This study aims to determine molecular erythropoietin gene expression and evaluate red cell indices as determinants of the severity of sickle cell disease.

Introduction: Thrombogenesis has been implicated in the development of sickle cell disease (SCD) pain episodes on the basis of clinical and pathological observations. The prognostic implication of elevated baseline platelet count is linked to disease severity. The aim of this study is to determine molecular thrombopoietin gene expression and evaluate platelet indices: its implications among sickle cell disease

Introduction : Chronic Lymphoproliferative Disorders (CLPDs) present a significant clinical challenge, characterised by the clonal proliferation of mature B lymphocytes and considerable biological and clinical heterogeneity. Cytogenetic analysis is pivotal in diagnosing and prognosticating these malignancies by identifying key chromosomal abnormalities, such as trisomies and deletions. However, data on the cytogenetic landscape of CLNs remain scarce in sub-Saharan Africa, particularly in Côte d’Ivoire.

Introduction: Helicobacter pylori (H pylori) is an infectious gram-negative bacterium that colonizes the gastric mucosa of about 4.4 billion people worldwide. It has been recognized as a key mediator of peptic ulcer, duodenal, and gastric cancers. The pathogenicity of H pylori is facilitated by its adherence to A B H and sialylated Lewis antigens present in the gastric mucosa via its BabA and SabA adhesins on its membrane. Thus, secretor status, A B O and Lewis blood group systems appear to play key roles in host microorganism interactions in H pylori infections. This study aimed to determine the prevalence and association of A B O, Lewis blood groups, and secretor status with H pylori infection.

Background: Picralima nitida and Cymbopogon citratus, traditionally used in West Africa, have gained interest for their potential health benefits. P. nitida shows antioxidant and anti-diabetic properties, while C. citratus exhibits anti-inflammatory and antioxidant effects. There is a need to study their ability to protect against benzene induced blood toxicity, potentially by influencing BCL-2 and BAD gene expression. This study aimed to evaluate the effects of aqueous leaf extracts from P. nitida and C. citratus on BCL-2 and BAD gene expression in rats with benzene-induced blood toxicity in albino Wistar rats.

Background: Hematological malignancies are group of cancers that arise from malignant transformation of cells of the bone marrow or lymphoid system. This study is aimed at determining the distribution of hematological malignancies, their clinical presentations and overall survival of subjects. Prospective cohort design with purposive sampling technique was employed in this study. Materials and method: Thirty-four newly diagnosed hematological malignancy patients presenting at University of Calabar Teaching Hospital were enrolled. Immunohistochemistry was employed for assessment of cluster of differentiation (CD) markers.

Background: Response to severe anaemia may be influenced by erythropoietin genotypes. This study assessed the relationship between erythropoietin gene variants and haematological

parameters among malaria-infected children.

Background: Human blood is a vital, irreplaceable component of life essential for sustaining critical physiological processes and enabling lifesaving procedures such as transfusions. Despite advances in research, no substitutes for human blood or its components exist thus placing humans as the only source of this vital component. The rate of voluntary blood donation in developing countries is relatively low, with most blood supplies coming from family replacement donors, and this practice has led to persistent shortages in meeting the growing demand for blood transfusion within these regions. Health science students and healthcare workers are strategically positioned to play a critical role in addressing this gap owing to their inherent health awareness, ethical responsibility and role modeling. Therefore, this study aimed to assess the perception, evaluate the practice of voluntary blood donation, and explore its motivators and barriers among health science students at Maflekumen University Institute Tiko.